CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese.
Identifieur interne : 002574 ( Main/Exploration ); précédent : 002573; suivant : 002575CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese.
Auteurs : Kelvin Yuen Kwong Chan [République populaire de Chine] ; Mei-Shu Xu ; Johannes Chi Yun Ching ; Thomas Man Kit So ; Sik-To Lai ; Chung-Ming Chu ; Loretta Y C. Yam ; Andrew T Y. Wong ; Pui Hong Chung ; Vera Sau Fong Chan ; Chen Lung Steve Lin ; Pak Chung Sham ; Gabriel M. Leung ; Joseph S M. Peiris ; Ui-Soon KhooSource :
- Human immunology [ 1879-1166 ] ; 2010.
Descripteurs français
- KwdFr :
- ADN (métabolisme), Adulte, Adulte d'âge moyen, Antigènes CD (génétique), Cellules HeLa, Facteur de transcription AP-2 (génétique), Facteur de transcription Sp1 (génétique), Femelle, Fréquence d'allèle (génétique), Génotype, Homozygote, Hong Kong, Humains, Hétérozygote, L-Lactate dehydrogenase (sang), Lectines de type C (génétique), Lectines de type C (métabolisme), Liaison aux protéines (génétique), Molécules d'adhérence cellulaire (génétique), Molécules d'adhérence cellulaire (métabolisme), Mâle, Polymorphisme de nucléotide simple (génétique), Population d'origine asiatique (génétique), Protéines nucléaires (métabolisme), Récepteurs de surface cellulaire (génétique), Récepteurs de surface cellulaire (métabolisme), Régions promotrices (génétique) (génétique), Sondes d'ADN (génétique), Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (sang), Test de retard de migration électrophorétique, Transfection.
- MESH :
- génétique : Antigènes CD, Facteur de transcription AP-2, Facteur de transcription Sp1, Fréquence d'allèle, Lectines de type C, Liaison aux protéines, Molécules d'adhérence cellulaire, Polymorphisme de nucléotide simple, Population d'origine asiatique, Récepteurs de surface cellulaire, Régions promotrices (génétique), Sondes d'ADN, Syndrome respiratoire aigu sévère.
- métabolisme : ADN, Lectines de type C, Molécules d'adhérence cellulaire, Protéines nucléaires, Récepteurs de surface cellulaire.
- sang : L-Lactate dehydrogenase, Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Cellules HeLa, Femelle, Génotype, Homozygote, Hong Kong, Humains, Hétérozygote, Mâle, Test de retard de migration électrophorétique, Transfection.
- Wicri :
- geographic : Hong Kong.
English descriptors
- KwdEn :
- Adult, Antigens, CD (genetics), Asian Continental Ancestry Group (genetics), Cell Adhesion Molecules (genetics), Cell Adhesion Molecules (metabolism), DNA (metabolism), DNA Probes (genetics), Electrophoretic Mobility Shift Assay, Female, Gene Frequency (genetics), Genotype, HeLa Cells, Heterozygote, Homozygote, Hong Kong, Humans, L-Lactate Dehydrogenase (blood), Lectins, C-Type (genetics), Lectins, C-Type (metabolism), Male, Middle Aged, Nuclear Proteins (metabolism), Polymorphism, Single Nucleotide (genetics), Promoter Regions, Genetic (genetics), Protein Binding (genetics), Receptors, Cell Surface (genetics), Receptors, Cell Surface (metabolism), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (genetics), Sp1 Transcription Factor (genetics), Transcription Factor AP-2 (genetics), Transfection.
- MESH :
- chemical , blood : L-Lactate Dehydrogenase.
- chemical , genetics : Antigens, CD, Cell Adhesion Molecules, DNA Probes, Lectins, C-Type, Receptors, Cell Surface, Sp1 Transcription Factor, Transcription Factor AP-2.
- chemical , metabolism : Lectins, C-Type, Nuclear Proteins, Receptors, Cell Surface.
- geographic : Hong Kong.
- blood : Severe Acute Respiratory Syndrome.
- genetics : Asian Continental Ancestry Group, Gene Frequency, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Protein Binding, Severe Acute Respiratory Syndrome.
- chemical , metabolism : Cell Adhesion Molecules, DNA.
- Adult, Electrophoretic Mobility Shift Assay, Female, Genotype, HeLa Cells, Heterozygote, Homozygote, Humans, Male, Middle Aged, Transfection.
Abstract
CD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro. In keeping with previously published findings, our in vitro studies confirmed that this SNP modulates gene promoter activity. Genetic association analysis of this SNP with clinico-pathologic outcomes in 824 serologic confirmed SARS patients showed that the -336AG/GG genotype SARS patients was associated with lower standardized lactate-dehydrogenase (LDH) levels compared with the -336AA patients (p = 0.014, odds ratio = 0.40). High LDH levels are known to be an independent predictor for poor clinical outcome, probably related to tissue destruction from immune hyperactivity. Hence, SARS patients with the CD209 -336 AA genotype carry a 60% chance of having a poorer prognosis. This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating.
DOI: 10.1016/j.humimm.2010.03.006
PubMed: 20359516
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001725
- to stream PubMed, to step Curation: 001725
- to stream PubMed, to step Checkpoint: 001705
- to stream Ncbi, to step Merge: 002105
- to stream Ncbi, to step Curation: 002105
- to stream Ncbi, to step Checkpoint: 002105
- to stream Main, to step Merge: 002612
- to stream Main, to step Curation: 002574
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese.</title><author><name sortKey="Chan, Kelvin Yuen Kwong" sort="Chan, Kelvin Yuen Kwong" uniqKey="Chan K" first="Kelvin Yuen Kwong" last="Chan">Kelvin Yuen Kwong Chan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Mei Shu" sort="Xu, Mei Shu" uniqKey="Xu M" first="Mei-Shu" last="Xu">Mei-Shu Xu</name></author><author><name sortKey="Ching, Johannes Chi Yun" sort="Ching, Johannes Chi Yun" uniqKey="Ching J" first="Johannes Chi Yun" last="Ching">Johannes Chi Yun Ching</name></author><author><name sortKey="So, Thomas Man Kit" sort="So, Thomas Man Kit" uniqKey="So T" first="Thomas Man Kit" last="So">Thomas Man Kit So</name></author><author><name sortKey="Lai, Sik To" sort="Lai, Sik To" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name></author><author><name sortKey="Chu, Chung Ming" sort="Chu, Chung Ming" uniqKey="Chu C" first="Chung-Ming" last="Chu">Chung-Ming Chu</name></author><author><name sortKey="Yam, Loretta Y C" sort="Yam, Loretta Y C" uniqKey="Yam L" first="Loretta Y C" last="Yam">Loretta Y C. Yam</name></author><author><name sortKey="Wong, Andrew T Y" sort="Wong, Andrew T Y" uniqKey="Wong A" first="Andrew T Y" last="Wong">Andrew T Y. Wong</name></author><author><name sortKey="Chung, Pui Hong" sort="Chung, Pui Hong" uniqKey="Chung P" first="Pui Hong" last="Chung">Pui Hong Chung</name></author><author><name sortKey="Chan, Vera Sau Fong" sort="Chan, Vera Sau Fong" uniqKey="Chan V" first="Vera Sau Fong" last="Chan">Vera Sau Fong Chan</name></author><author><name sortKey="Lin, Chen Lung Steve" sort="Lin, Chen Lung Steve" uniqKey="Lin C" first="Chen Lung Steve" last="Lin">Chen Lung Steve Lin</name></author><author><name sortKey="Sham, Pak Chung" sort="Sham, Pak Chung" uniqKey="Sham P" first="Pak Chung" last="Sham">Pak Chung Sham</name></author><author><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M" last="Leung">Gabriel M. Leung</name></author><author><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S M" last="Peiris">Joseph S M. Peiris</name></author><author><name sortKey="Khoo, Ui Soon" sort="Khoo, Ui Soon" uniqKey="Khoo U" first="Ui-Soon" last="Khoo">Ui-Soon Khoo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20359516</idno><idno type="pmid">20359516</idno><idno type="doi">10.1016/j.humimm.2010.03.006</idno><idno type="wicri:Area/PubMed/Corpus">001725</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001725</idno><idno type="wicri:Area/PubMed/Curation">001725</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001725</idno><idno type="wicri:Area/PubMed/Checkpoint">001705</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001705</idno><idno type="wicri:Area/Ncbi/Merge">002105</idno><idno type="wicri:Area/Ncbi/Curation">002105</idno><idno type="wicri:Area/Ncbi/Checkpoint">002105</idno><idno type="wicri:Area/Main/Merge">002612</idno><idno type="wicri:Area/Main/Curation">002574</idno><idno type="wicri:Area/Main/Exploration">002574</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese.</title><author><name sortKey="Chan, Kelvin Yuen Kwong" sort="Chan, Kelvin Yuen Kwong" uniqKey="Chan K" first="Kelvin Yuen Kwong" last="Chan">Kelvin Yuen Kwong Chan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Mei Shu" sort="Xu, Mei Shu" uniqKey="Xu M" first="Mei-Shu" last="Xu">Mei-Shu Xu</name></author><author><name sortKey="Ching, Johannes Chi Yun" sort="Ching, Johannes Chi Yun" uniqKey="Ching J" first="Johannes Chi Yun" last="Ching">Johannes Chi Yun Ching</name></author><author><name sortKey="So, Thomas Man Kit" sort="So, Thomas Man Kit" uniqKey="So T" first="Thomas Man Kit" last="So">Thomas Man Kit So</name></author><author><name sortKey="Lai, Sik To" sort="Lai, Sik To" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name></author><author><name sortKey="Chu, Chung Ming" sort="Chu, Chung Ming" uniqKey="Chu C" first="Chung-Ming" last="Chu">Chung-Ming Chu</name></author><author><name sortKey="Yam, Loretta Y C" sort="Yam, Loretta Y C" uniqKey="Yam L" first="Loretta Y C" last="Yam">Loretta Y C. Yam</name></author><author><name sortKey="Wong, Andrew T Y" sort="Wong, Andrew T Y" uniqKey="Wong A" first="Andrew T Y" last="Wong">Andrew T Y. Wong</name></author><author><name sortKey="Chung, Pui Hong" sort="Chung, Pui Hong" uniqKey="Chung P" first="Pui Hong" last="Chung">Pui Hong Chung</name></author><author><name sortKey="Chan, Vera Sau Fong" sort="Chan, Vera Sau Fong" uniqKey="Chan V" first="Vera Sau Fong" last="Chan">Vera Sau Fong Chan</name></author><author><name sortKey="Lin, Chen Lung Steve" sort="Lin, Chen Lung Steve" uniqKey="Lin C" first="Chen Lung Steve" last="Lin">Chen Lung Steve Lin</name></author><author><name sortKey="Sham, Pak Chung" sort="Sham, Pak Chung" uniqKey="Sham P" first="Pak Chung" last="Sham">Pak Chung Sham</name></author><author><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M" last="Leung">Gabriel M. Leung</name></author><author><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S M" last="Peiris">Joseph S M. Peiris</name></author><author><name sortKey="Khoo, Ui Soon" sort="Khoo, Ui Soon" uniqKey="Khoo U" first="Ui-Soon" last="Khoo">Ui-Soon Khoo</name></author></analytic><series><title level="j">Human immunology</title><idno type="eISSN">1879-1166</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, CD (genetics)</term><term>Asian Continental Ancestry Group (genetics)</term><term>Cell Adhesion Molecules (genetics)</term><term>Cell Adhesion Molecules (metabolism)</term><term>DNA (metabolism)</term><term>DNA Probes (genetics)</term><term>Electrophoretic Mobility Shift Assay</term><term>Female</term><term>Gene Frequency (genetics)</term><term>Genotype</term><term>HeLa Cells</term><term>Heterozygote</term><term>Homozygote</term><term>Hong Kong</term><term>Humans</term><term>L-Lactate Dehydrogenase (blood)</term><term>Lectins, C-Type (genetics)</term><term>Lectins, C-Type (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Nuclear Proteins (metabolism)</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Promoter Regions, Genetic (genetics)</term><term>Protein Binding (genetics)</term><term>Receptors, Cell Surface (genetics)</term><term>Receptors, Cell Surface (metabolism)</term><term>Severe Acute Respiratory Syndrome (blood)</term><term>Severe Acute Respiratory Syndrome (genetics)</term><term>Sp1 Transcription Factor (genetics)</term><term>Transcription Factor AP-2 (genetics)</term><term>Transfection</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN (métabolisme)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes CD (génétique)</term><term>Cellules HeLa</term><term>Facteur de transcription AP-2 (génétique)</term><term>Facteur de transcription Sp1 (génétique)</term><term>Femelle</term><term>Fréquence d'allèle (génétique)</term><term>Génotype</term><term>Homozygote</term><term>Hong Kong</term><term>Humains</term><term>Hétérozygote</term><term>L-Lactate dehydrogenase (sang)</term><term>Lectines de type C (génétique)</term><term>Lectines de type C (métabolisme)</term><term>Liaison aux protéines (génétique)</term><term>Molécules d'adhérence cellulaire (génétique)</term><term>Molécules d'adhérence cellulaire (métabolisme)</term><term>Mâle</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Population d'origine asiatique (génétique)</term><term>Protéines nucléaires (métabolisme)</term><term>Récepteurs de surface cellulaire (génétique)</term><term>Récepteurs de surface cellulaire (métabolisme)</term><term>Régions promotrices (génétique) (génétique)</term><term>Sondes d'ADN (génétique)</term><term>Syndrome respiratoire aigu sévère (génétique)</term><term>Syndrome respiratoire aigu sévère (sang)</term><term>Test de retard de migration électrophorétique</term><term>Transfection</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>L-Lactate Dehydrogenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, CD</term><term>Cell Adhesion Molecules</term><term>DNA Probes</term><term>Lectins, C-Type</term><term>Receptors, Cell Surface</term><term>Sp1 Transcription Factor</term><term>Transcription Factor AP-2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lectins, C-Type</term><term>Nuclear Proteins</term><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hong Kong</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asian Continental Ancestry Group</term><term>Gene Frequency</term><term>Polymorphism, Single Nucleotide</term><term>Promoter Regions, Genetic</term><term>Protein Binding</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes CD</term><term>Facteur de transcription AP-2</term><term>Facteur de transcription Sp1</term><term>Fréquence d'allèle</term><term>Lectines de type C</term><term>Liaison aux protéines</term><term>Molécules d'adhérence cellulaire</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine asiatique</term><term>Récepteurs de surface cellulaire</term><term>Régions promotrices (génétique)</term><term>Sondes d'ADN</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cell Adhesion Molecules</term><term>DNA</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ADN</term><term>Lectines de type C</term><term>Molécules d'adhérence cellulaire</term><term>Protéines nucléaires</term><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>L-Lactate dehydrogenase</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Electrophoretic Mobility Shift Assay</term><term>Female</term><term>Genotype</term><term>HeLa Cells</term><term>Heterozygote</term><term>Homozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Transfection</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cellules HeLa</term><term>Femelle</term><term>Génotype</term><term>Homozygote</term><term>Hong Kong</term><term>Humains</term><term>Hétérozygote</term><term>Mâle</term><term>Test de retard de migration électrophorétique</term><term>Transfection</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hong Kong</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">CD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro. In keeping with previously published findings, our in vitro studies confirmed that this SNP modulates gene promoter activity. Genetic association analysis of this SNP with clinico-pathologic outcomes in 824 serologic confirmed SARS patients showed that the -336AG/GG genotype SARS patients was associated with lower standardized lactate-dehydrogenase (LDH) levels compared with the -336AA patients (p = 0.014, odds ratio = 0.40). High LDH levels are known to be an independent predictor for poor clinical outcome, probably related to tissue destruction from immune hyperactivity. Hence, SARS patients with the CD209 -336 AA genotype carry a 60% chance of having a poorer prognosis. This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chan, Vera Sau Fong" sort="Chan, Vera Sau Fong" uniqKey="Chan V" first="Vera Sau Fong" last="Chan">Vera Sau Fong Chan</name><name sortKey="Ching, Johannes Chi Yun" sort="Ching, Johannes Chi Yun" uniqKey="Ching J" first="Johannes Chi Yun" last="Ching">Johannes Chi Yun Ching</name><name sortKey="Chu, Chung Ming" sort="Chu, Chung Ming" uniqKey="Chu C" first="Chung-Ming" last="Chu">Chung-Ming Chu</name><name sortKey="Chung, Pui Hong" sort="Chung, Pui Hong" uniqKey="Chung P" first="Pui Hong" last="Chung">Pui Hong Chung</name><name sortKey="Khoo, Ui Soon" sort="Khoo, Ui Soon" uniqKey="Khoo U" first="Ui-Soon" last="Khoo">Ui-Soon Khoo</name><name sortKey="Lai, Sik To" sort="Lai, Sik To" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M" last="Leung">Gabriel M. Leung</name><name sortKey="Lin, Chen Lung Steve" sort="Lin, Chen Lung Steve" uniqKey="Lin C" first="Chen Lung Steve" last="Lin">Chen Lung Steve Lin</name><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S M" last="Peiris">Joseph S M. Peiris</name><name sortKey="Sham, Pak Chung" sort="Sham, Pak Chung" uniqKey="Sham P" first="Pak Chung" last="Sham">Pak Chung Sham</name><name sortKey="So, Thomas Man Kit" sort="So, Thomas Man Kit" uniqKey="So T" first="Thomas Man Kit" last="So">Thomas Man Kit So</name><name sortKey="Wong, Andrew T Y" sort="Wong, Andrew T Y" uniqKey="Wong A" first="Andrew T Y" last="Wong">Andrew T Y. Wong</name><name sortKey="Xu, Mei Shu" sort="Xu, Mei Shu" uniqKey="Xu M" first="Mei-Shu" last="Xu">Mei-Shu Xu</name><name sortKey="Yam, Loretta Y C" sort="Yam, Loretta Y C" uniqKey="Yam L" first="Loretta Y C" last="Yam">Loretta Y C. Yam</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Chan, Kelvin Yuen Kwong" sort="Chan, Kelvin Yuen Kwong" uniqKey="Chan K" first="Kelvin Yuen Kwong" last="Chan">Kelvin Yuen Kwong Chan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002574 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002574 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:20359516
|texte= CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20359516" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |